A driver has been seriously injured after crashing into a house on the back of a wide-load truck north of Brisbane.

A ute has collided with an oversized truck transporting a house north of Brisbane.

The crash occurred shortly after 3am Friday at Curra on the Bruce Highway, near Gympie.

A man driving his ute south collided with the wide-load truck, which was being escorted by police.

The driver of the ute was taken to Gympie Hospital in a serious condition.

The highway remains closed.