Police say a missing 71-year-old man reported missing by his Brisbane-based daughter may have been murdered.

Police believe a 71-year-old man last seen in Brisbane almost a fortnight ago may have been murdered.

Homicide investigators have been called in and a crime scene has been set up at a house in Slacks Creek where David Hanson was last seen on February 22.

Mr Hanson, who spends his time between South Africa and Australia, was reported missing by his daughter last Sunday.

Police say his disappearance is suspicious and they’re investigating the possibility he may have been murdered.

“We seriously are considering the fact that a homicide has taken place and we do hold grave concerns for his safety,” Detective Superintendent Dave Hutchinson said on Thursday.

“It’s difficult to say (whether he was murdered) as this is very early stages but we have sufficient concern for his welfare that we are investigating the matter and do have homicide detectives involved.”

Supt Hutchinson says the missing man was due to fly out of Brisbane to South Africa on February 22.

He met his daughter at a Brisbane cafe before returning to the Slacks Creek house where he had been staying with a friend.

His friend told police Mr Hanson left the house about noon to catch a flight to South Africa.

“He didn’t make it to the airport and has hasn’t been seen since that time,” Supt Hutchinson said.

Police want to speak to anyone who may have seen Mr Hanson in the Brisbane area.

He is described as being Caucasian in appearance, about 170cm tall and has a slim build, a bald head and a moustache.

Supt Hutchinson said Mr Hanson arrived in Australia from South Africa on February 18.

He said police wanted to speak to anyone who knew anything about Mr Hanson’s business dealings involving mining operations in South Africa.

But Supt Hutchinson said it was too early to say whether there were any financial motives behind Mr Hanson’s disappearance.

“We still have a lot of inquiries to conduct at this stage in relation to his actual business deals,” he said.

“I don’t think the mines are significantly profitable at this point but this is all still to be confirmed… but there’s nothing to suggest he’s a wealthy man.”

Sup Hutchinson said several people lived at the house where Mr Hanson was last seen.