An inner-city Brisbane street will reportedly close for six years, and 50 bus routes will be changed before Christmas, as work begins on the new Queens Wharf Casino.

Fairfax reports that William Street, which is currently used by 8000 vehicles each day, will be closed between Elizabeth Street and Margaret Street before Christmas, and will stay closed for six years.

The closure will allow for the demolition of the Executive Building (between George and William streets) and the Neville Bonner Building (on William Street) in early January 2017, followed by major construction.

Access to and from the Riverside Expressway will reportedly remain open, but there will be no right hand turns from Elizabeth Street into William Street, and no left hand turns from Margaret Street into William Street, for six years.

The closure will require changes to more than 50 bus routes, as well as major upgrades to 11 intersections to create new bus routes through the city, changes to pedestrian walking zones, new taxi pick-up areas and alternate access to some hotels, with a construction bill of almost $10 million.

Brisbane City Council is expected to ask the Queensland Government to cover the cost of the changes.

Translink and Brisbane City Council are expected to provide official confirmation of the new bus routes soon, as well as new bus stops in Mary Street and Charlotte Street and changes to cycle ways.

If all goes to plan, Queens Wharf Resort — a project of the state government, as well as the Destination Brisbane consortium made up of The Star Entertainment Group, Far East Consortium and Chow Tai Fook Enterprises — will open in 2022.